PAT-Enabled Automated Feedforward Control: an Application to the Continuous Manufacture of Apremilast

Hsiao-Wu Hsieh,Daniel J. Griffin, Anirudh M. K. Nambiar, Nandini Sarkar, Hamza Youssef Ismail, Kartik Saigal,Dongying Erin Shen, Nicole Goudas-Salomon, Rasangi Wimalasinghe,Alicia Zeng,Oliver R. Thiel,Matthew G. Beaver

Organic Process Research & Development（2024）

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Key words

Otezla,apremilast,continuous manufacturing,flow chemistry,feedforward control,lab automation,process analytical technologies

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