Cancer-related Fatigue among Patients with Advanced Cancer Receiving Immune-Checkpoint Inhibitors: a Prospective Study
Supportive care in cancer official journal of the Multinational Association of Supportive Care in Cancer(2024)
摘要
The aim of this study was to determine the frequency and factors associated with severity of cancer related fatigue (CRF) as assessed by Functional Assessment of Cancer Illness Therapy–Fatigue (FACIT-F), prior to, and during 12 weeks of immune-checkpoint inhibitors (ICIs). We also explored the effects of ICIs on fatigue dimensions and interference with daily activities (Multidimensional Functional Symptom Inventory, MFSI-SF, Patient-Related Outcome Symptom Measurement Information System Short form Fatigue 7a, PROMIS F-SF), QOL (Functional Assessment of Cancer Therapy-General, FACT-G), and cancer symptoms (Edmonton Symptom Assessment Scale, ESAS). In this prospective, longitudinal observational study, patients with a diagnosis of advanced cancer receiving ICIs were evaluated. Patient demographics, FACT-G, FACIT-F, MFSI-SF, PROMIS F-SF, and ESAS were collected prior to, and during 12 weeks of ICIs. A total of 160 of the 212 enrolled patients were analyzed. The median age was 61 years, 60
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关键词
Fatigue,Cancer,Immunotherapy,Adverse event,Immune-checkpoint inhibitors
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