Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024.

Mira C Patel, Ha T Nguyen,Philippe Noriel Q Pascua, Rongyuan Gao,John Steel, Rebecca J Kondor, Larisa V Gubareva

Emerging infectious diseases（2024）

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摘要

Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.

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关键词

Influenza,antiviral,neuraminidase inhibitors,oseltamivir,reduced inhibition,substitution

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