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NAMPT-targeting PROTAC and Nicotinic Acid Co-Administration Elicit Safe and Robust Anti-Tumor Efficacy in NAPRT-deficient Pan-Cancers

Xiaotong Zhu, Ye Li,Haixia Liu,Yuetong Wang,Renhong Sun, Zhenzhou Jiang,Chun Hou, Xianyu Hou, Suming Huang, Huijuan Zhang,Haopeng Wang, Biao Jiang,Xiaobao Yang,Bin Xu,Gaofeng Fan

Cell chemical biology（2024）

引用 1|浏览4
关键词
metabolism,NAD+,NAMPT,PROTAC,synthetic lethality,NAPRT,nicotinic acid
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