Cryogenic cesium iodide as a potential PET material

Total-body PET (TB-PET) scanners, with axial lengths exceeding 1 meter, provide significantly higher sensitivity than conventional PET scanners due to their greater acceptance of gamma pairs. However, this increased sensitivity often comes from gamma rays detected at oblique angles, leading to substantial multiple scattering along the patient's body. Additionally, the cost of TB-PET scanners scales with their extended detector length, often costing 5 to 10 times more than conventional scanners. Therefore, optimizing TB-PET performance requires crystals that enhance energy resolution and control costs. Cesium iodide (CsI), though historically less favored for PET due to its lower stopping power and light yield compared to crystals like LYSO, shows remarkable improvement when operated at cryogenic temperatures (∼100 K). Under these conditions, CsI light yield rises dramatically to about 100 photons/keV, providing excellent energy resolution and good coincidence time resolution at a lower cost - typically 3 to 5 times cheaper than other crystals at parity of radiation length. In our study, cryogenic CsI crystals achieved an energy resolution better than 7 These results demonstrate the potential of cryogenic CsI as a cost-effective, high-performance material for TB-PET scanners.