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Structures Reveal How SGLT Inhibitors Work.

Zejian Sun,Wenhao Cui,Lei Chen

Trends in Pharmacological Sciences（2024）

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Abstract
Sodium glucose cotransporters (SGLTs) transport glucose against its concentration gradient by harnessing the electrochemical potential gradient of sodium ions. SGLT inhibitors are widely prescribed to treat diabetes and other conditions. Recent structural studies have uncovered how chemically diverse SGLT inhibitors bind and inhibit the transporter at the atomic level.
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Key words
SGLT,diabetes,gliflozin,glucose
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