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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

Kumar Ganesan, Cong Xu, Jianming Wu,Bing Du, Qingqing Liu,Yue Sui,Cailu Song, Jinhui Zhang,Hailin Tang,Jianping Chen

Science China Life Sciences（2024）

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Abstract
The spreading of cancer cells from the primary tumor site to other parts of the body, known as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer (TNBC). Overexpression of epidermal growth factor receptor (EGFR) is observed in approximately 70
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Key words
ononin,TNBC,breast cancer lung metastasis,EGFR,PI3k/Akt,EMT,therapeutic effect
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