Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

Yifei Lu,Zhongyuan Guo, Yujie Zhang,Chao Li, Yu Zhang, Qin Guo,Qinjun Chen,Xinli Chen, Xi He,Lisha Liu,Chunhui Ruan, Tao Sun,Bin Ji,Weigen Lu,Chen Jiang

Advancement of science（2019）

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Abstract

An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co‐workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an early phase of AD. Through its efficient neuroprotection and microglia modulatory functions, decreased Aβ plaque burdens and improved cognition are achieved.

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