Insights from HIV-1 vaccine and passive immunization efficacy trials
Trends in Molecular Medicine（2024）
Abstract
An effective HIV-1 vaccine is still not available, and most vaccine efficacy trials conducted over the years resulted in no significant overall protection. Here we highlight several insights gained from these trials as well as emerging questions that may be important for further guidance to advance current research directions.
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Key words
HIV-1 vaccines,vaccine efficacy trials,antibody-mediated protection,broadly neutralizing antibodies,antibody-mediated cell cytotoxicity
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