Assessing Organic Electrochemical Transistors for Biosensing Applications with Seminal Fluid

The primary objective of bioanalytical chemistry is the detection of biomarkers at ultra-low concentrations, particularly when these biomarkers are associated with pathological conditions. The ability to detect these biomarkers enables the rapid and accurate diagnosis of diseases. However, detecting substances at the molecular level remains a substantial limitation in Point of Care diagnostics, as recently exemplified by the COVID-19 pandemic. Consequently, there is a clear imperative to develop cost-effective digital technologies capable of precisely monitoring specific analytes, thereby quantifying the transition of an organism from a healthy to a diseased state in a lucid and expeditious manner. In this context, organic electrochemical transistors (OECTs) have emerged as promising platforms for biosensing applications, offering unique advantages such as low-cost fabrication, compatibility with flexible substrates, and biocompatibility. This contribution explores the significance of OECTs in biosensing, particularly focusing on their utilization with biological fluids like seminal fluid which is, according to our knowledge, not reported in the literature so far. The use of seminal fluid in biosensing holds significant clinical relevance, especially in the assessment of male reproductive health and fertility. OECT-based biosensors offer sensitive detection capabilities, enabling the quantification of specific biomarkers present in seminal fluid. By leveraging the electrochemical properties of seminal fluid constituents, OECTs can provide rapid, label-free, and real-time monitoring, facilitating timely diagnostics and personalized treatment strategies.