Highly regioselective synthesis of branched saturated aldehydes by tandem hydroformylation/isomerization/hydrogenation of 1-arylbutadienes

Rh-catalyzed tandem hydroformylation/isomerization/hydrogenation of various 1-arylbutadienes toward the corresponding branched saturated aldehydes were performed in the presence of monodentate phosphine ligand PPh3. After investigating different reaction parameters such as P-ligands and solvents, the conversion of substrates (including electron withdrawing and electron donating groups on aromatic rings, up to 99