Strain Sensor on Chip for Quantifying the Magnitudes of Tensile Stress on Cells

We designed a cell stretching platform with a in-situ sensor, the sensors can accurately measure the mechanical stimulation caused by the deformation of the vacumm cavity exerted on cells. The platform was applied to human cardiomyocytes (AC16) with cyclic strain (5%, 10%, 15%, 20%, 25%), and we found that cyclic strain promoted cell growth, induced the arrangement of cells on the membrane to gradually unify in consistency, and stabilized at 15% amplitude stimulation, which was even more effective after 3 days of culture.