Blending polymer outer membrane for continuous glucose monitoring with an extended lifetime

Continuous glucose monitoring (CGM) systems are valuable for managing glucose levels. They provide insight into how glucose is affected by factors such as physical activity, drugs, and food intake. However, the lifetime of commercially implanted CGM sensors has been limited to around 15 days due to tissue rejection. As an important part of sensors, the outer membrane selection deters sensors' lifetime and in vivo stability. In this study, a biocompatible outer membrane based on the blending of Chronosil and HydroMed is developed and investigated on the glucose sensors. Results show that the sensors on non-diabetic beagles can work for at least 21 days with accurate results. This new material could extend the lifetime of implanted CGM sensors and improve in vivo stability, making them more useful for managing diabetes.