Copper and Silver Nano-Schiff Base Complexes: Efficient Catalysts for Triazole Synthesis and Antimicrobial assessment

1,2,3-Triazoles are one of the most important nitrogen-containing five-membered heterocycles and have a wide range of applications in pharmaceuticals, chemical biology, and industry. Therefore, the development of facile and straightforward methodology for the synthesis of 1,2,3-triazoles is of noteworthy interest. Click chemistry represents the most facile, easy and one pot reaction method to synthesize catalyzed azide–alkyne cycloaddition reaction. Nano-scaled bis(2-hydroxy-1-naphthylmethylidene) ethane-1,2-diamine copperII [CuSB1] and nano-silver ethane-1,2-diamine bis(2-hydroxy-1-naphthylmethylidene) [AgHSB2] complexes where H2SB= 1,2-diamino ethane-N,N’-bis(2-hydroxy-1-naphthylmethylidene), were synthesized utilizing ultrasonic green method. The catalysts were examined by elemental analyses, molar conductance, and spectrophotometric tests. The optimized geometrical structures of H2SB, [CuSB1], [AgHSB2], and HOMO–LUMO representations were performed by Cluster calculations using DMOL3 program. TEM images showed narrower morphology and regular nanostructures of the catalysts. CuSB1] and [AgHSB2] exhibit efficient catalytic activity to prepare different triazoles (3-8). using single-pot selective cycloaddition reaction within very short time and excellent yield without presence of biproducts. The complexes [CuSB1], [AgHSB2] and the triazoles 3, 4, as representative examples, have efficient antimicrobial activity making them promising drugs for treating the bacterial and fungal infections.