Supplementary Figures 1-7 from Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13

Fig. S1. The ENCODE ChIP-Seq data showing histone marks in the 9p21 locus of human mammary epithelial cells (HMEC). Fig. S2. CNV-seq analysis of the 9p21-deleted clones compared to wt-9p21 clones. Fig. S3. CDKN2A or CDKN2B knockdown does not promote cell transformation. Fig. S4. The 4C analysis of the 9p21 interactions. Fig. S5. The effect of CDKN2A loss on expression of the 9p21 interacting genes. Fig.S6. The effect of the 9p21 interacting genes on growth of kidney cells. Fig. S7. HOXB13 expression and 9p21 status in ccRCC tissues