Oncostatin M Reverses ABCG2-mediated Mitoxantrone Resistance.
Biomedicine & pharmacotherapy(2024)
Abstract
Mitoxantrone resistant variant of SW620 line was developed, characterized and subsequently used as a model system to determine oncostatin M ability to modulate MDR phenomenon. The selection regimen allowed for overexpression of ABCG2 and ABCB1 both at the RNA and protein level, which was further confirmed by functional assays. Oncostatin M supplementation resulted in partial reversal of MDR phenotype by decreasing overexpression of ABCG2 demonstrating for the first time the ability of this cytokine for selective down-regulation of one of MDR proteins.
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Key words
Oncostatin M mitoxantrone Multidrug resistance
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