Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS^G12D-Mediated Pancreatic Cancer

Figure S1. Elevated SRSF1 induces pancreatitis and is associated with its duration. Figure S2. Elevated SRSF1 predicts poor PDAC clinical prognosis and is associated with PDAC progression. Figure S3. SRSF1 accelerates KRASG12D-mediated PDAC tumorigenesis. Figure S4. SRSF1 loss delays KRASG12D-mediated PDAC initiation. Figure S5. Opposite patterns of pathway enrichment by KRASG12D mutation versus SRSF1 upregulation. Figure S6. Recombination and activation of KrasG12D allele in pancreas cells from KC mice. Figure S7. KSC and KPSC mice exhibit a hyper-activated MAPK pathway, suppression of which diminished SRSF1-induced pancreatitis. Figure S8. Decreased SRSF1 expression perturbs MAPK signaling. Figure S9. MYC promotes SRSF1 expression in PDAC. Figure S10. SRSF1 regulates IL1R1 alternative splicing and expression. Figure S11. Knockout of Il1r1 rescues SRSF1-induced pancreatitis. Table S1. Oligonucleotides for PCR and short hairpin RNAs.