Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel

Journal of Hematology & Oncology(2024)

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摘要
Idecabtagene vicleucel (Ide-cel) has demonstrated excellent efficacy and durable responses in patients with relapsed/refractory multiple myeloma (RRMM). However, the outcomes with ide-cel in patients with extramedullary disease (EMD) remain incompletely characterized. We included patients with RRMM treated with ide-cel between May 2021 and April 2023 across 11 US academic institutions. Visceral or soft tissue lesions non-contiguous from bone was classified as EMD. Time-to-event analyses were performed from date of ide-cel infusion. Among 351 patients, 84 (24
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关键词
BCMA CAR-T,Ide-cel,Relapsed/refractory myeloma,Radiation,Immunotherapy
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