Supplementary Figure S7 from Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study

Supplementary Figure S7: Antibiotics use in relation to overall and cancer-specific survival in stage IV colorectal cancer by antibiotics classes, typical indications and specific antibiotics drugs. The hazards ratios (HR) are derived from the Cox proportional hazards models, stratified by tumour sites (proximal colon, distal colon, rectum, unspecified), sex (male/female), age at diagnosis (≥ 50 years), prediagnostic Charlson comorbidity index (no/any comorbidity), income status (1st/2nd/3rd/4th quartile), and adjusted for age and calendar year of diagnosis and prediagnostic Charlson comorbidity index as continuous variables, place of birth, county, marital status, level of education, family history of colorectal cancer, palliative chemotherapy and surgical therapy as categorical variables, defined as presented in Supplementary Table S4. Any use of specific antibiotics class was compared to no reported use of specific antibiotics class (reference). Antibiotics use during one year before colorectal cancer diagnosis was excluded to account for potential use due to undiagnosed but clinically manifest colorectal cancer. Antibiotics that primarily or only affect aerobic bacteria were categorized as anti-aerobic antibiotics. Antibiotics with effect on both 2 anaerobic and aerobic bacteria, and metrodinazoles and/or tinidazoles (which only affect anaerobic bacteria) were categorized as anti-anaerobic antibiotics. Phenoxymethylpenicillin is presented as a specific antibiotic drug but was also the sole typical drug for the indication uncomplicated respiratory infections and some skin and soft tissue infections. Clindamycin is presented as a specific antibiotic drug but was also the sole typical drug for the indication complicated skin and soft tissue and deep-seated infections. Amoxicillin includes amoxicillin with beta-lactamase inhibitor. UTI = urinary tract infection, CI = confidence interval. Detailed antibiotics classification and typical indications are presented in Supplementary Table S1.