Supplementary Figures S1 - S6 from Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition
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摘要
Supplementary Figure S1 - Validation of CCNE1 and CDK2 siRNA-mediated knockdown Supplementary Figure S2 - Validation of CDK2 knockdown mediated by shRNA in vitro and in vivo Supplementary Figure S3 - FACS plots validating incorporation and induction of shRNA into OVCAR3 and CAOV3 cells Supplementary Figure S4 - Characterisation of CDK resistant lines and supplementary data supporting drug treatment Supplementary Figure S5 - Extended Oncoprint figure from TCGA Supplementary Figure S6 - Validation of FT282 over-expression constructs
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