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Rapid End-Game Process Development and First GMP Production of MK-7845: an Experimental Antiviral Treatment for COVID-19

Nicholas R. Deprez,Jonathan M. E. Hughes, Shorouk O. Badir,Stasik Popov,Teresa Andreani,Rachel S. Bade,Clara Hartmanshenn,Thomas Tai-min Kwok,Donald R. Gauthier Jr,Nastaran Salehi Marzijarani, Zeinab Sakhaei, Riki Drout,Steve Castro,David J. Schenk, Charles Wolstenholme, Nilusha Padivitage, Cody Welch, Jason R. Kowalski,Brittany Kassim,Yong Liu,Ryan D. Cohen,Alex M. Confer,Guilherme Dal Poggetto,Andrew P. J. Brunskill,Feng Peng,Ji Qi, Jing Xu,Mingxiang Lin,Jamie M. McCabe Dunn

Organic Process Research & Development（2024）

Cited 1|Views3

Key words

SARS-CoV-2,COVID-19,TEMPO oxidation,amide coupling,crystallization

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