Supplementary Figure S5 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

Fig. S5. RNA sequencing of PDAC cells. (A) Volcano plot showing upregulated (1145) and downregulated (183) genes in T3M4-WT and T3M4-MUC16KO cells (n=3); (B) Gene set enrichment analysis (GSEA) plot showing enrichment of apoptosis in T3M4-MUC16KO cells. (C) Log2FoldChange (Lof2FC) of MUC16KO versus WT and (D) Fragments Per Kilobase of transcript per Million (FPKM) of genes affected in EGF signaling pathway. p < 0.05 was considered as statistically significant.