Supplementary Figure S2 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Somatic mutation rates in FAP and MAP-associated duodenal adenomas. A. Total, non-silent and silent mutation rate for all FAP and MAP adenomas. For FAP-associated duodenal adenomas, the average total mutation rate was 3.3 mutations per Mb (0.33-10.65 mutations/Mb), whilst for MAP adenomas, it was 4.9 mutations per Mb (0.94-15.1 mutations/Mb). The average non-silent mutational rate for FAP duodenal adenomas was 1.96 non-silent mutations/Mb (0.23-7.69 mutations/Mb), whilst for MAP adenomas it was 2.95 non-silent mutations/Mb (0.43-8.44 mutations/Mb). B. Differences in total, non-silent and silent mutational rates between the two diseases. There were no significant differences in total, non-silent and silent mutational rates between the two diseases. n.s. P>0.05; * P ≤0.05; ** P≤0.01; *** P ≤0.001.