3D printed needleless injector based on thermocavitation: analysis of impact and penetration depth in skin phantoms in a repetitive regime

Rafael Zaca-Morán, Doris Giovanna Mitre-Martínez, Juan Castillo-Mixcóalt,Placido Zaca-Morán,Rubén Ramos-García,Julio César Ramírez-San-Juan, Carolina Morán-Raya,Juan Pablo Padilla-Martínez

Drug Delivery and Translational Research(2024)

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Abstract
A global issue that requires attention is the duality between the shortage of needles for regular vaccination campaigns and the exponential increase in syringe and needle waste from such campaigns, which has been exacerbated by the COVID-19 pandemic. In response to this problem, this study presents a 3D printed needleless injector based on thermocavitation. The work focused on investigating the interaction of the resulting liquid jets with skin phantoms at different concentrations (1–2
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Key words
Needleless injector,Thermocavitation,3D printed,Penetration depth,Repetitive regime
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