Effects of the composition of food and medicine homologous ingredients complex supplementation on lipid metabolism and gut microbiota diversity in high‐fat diet‐induced obese mice

Dietary patterns are closely related to obesity, and a balanced diet can prevent obesity more than a single food or nutrient. In this study, we investigated the anti‐obesity effects of food and medicine homologous ingredient complex (FMHIC). The serum biochemical indices related to lipid metabolism were significantly improved in the FMHIC group. Meanwhile, it significantly inhibited the accumulation of lipid droplets, improved adipocyte hypertrophy and downregulated gene expression related to lipid production. FMHIC can effectively regulate intestinal flora richness and structural disorder in obese mice and result in a higher abundance of NK4A214_group and Prevotellaceae _UCG_001, and a lower abundance of Negativibacillus, Lachnospiraceae_NK4A136_group, Lachnoclostridium and GCA_900066575. Spearman correlation analysis showed that there was a strong correlation between species richness and lipid metabolism and that FMHIC might adjust lipid metabolism by regulating the abundance of intestinal flora. In conclusion, FMHIC regulates lipid metabolism and modulates gut microbiota to regulate high‐fat diet‐induced dysbiosis.