Microbiome Miracles and their Pioneering Advances and Future Frontiers in Cardiovascular Disease

Mishal Safdar,Muneeb Ullah,Shah Hamayun,Abdul Wahab,Shahid Ullah Khan, Sidikov Akmal Abdikakhorovich, Zia Ul Haq, Aqsa Mehreen,Muhammad Naeem,Apon Zaenal Mustopa,Nurhasni Hasan

Current Problems in Cardiology(2024)

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摘要
Cardiovascular diseases (CVDs) represent a significant global health challenge, underscoring the need for innovative approaches to prevention and treatment. Recent years have seen a surge in interest in unraveling the complex relationship between the gut microbiome and cardiovascular health. This article delves into current research on the composition, diversity, and impact of the gut microbiome on CVD development. Recent advancements have elucidated the profound influence of the gut microbiome on disease progression, particularly through key mediators like Trimethylamine-N-oxide (TMAO) and other microbial metabolites. Understanding these mechanisms reveals promising therapeutic targets, including interventions aimed at modulating the gut microbiome's interaction with the immune system and its contribution to endothelial dysfunction. Harnessing this understanding, personalized medicine strategies tailored to individuals' gut microbiome profiles offer innovative avenues for reducing cardiovascular risk. As research in this field continues to evolve, there is vast potential for transformative advancements in cardiovascular medicine, paving the way for precision prevention and treatment strategies to address this global health challenge.
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关键词
Cardiovascular Disease Prevention,Gut-Cardiovascular Connection,Microbial Epigenetics,Cardiovascular Health
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