Development of alcoholic dyslipidemia syndrome — social security violation factor in the Arctic region.

Alcoholism aggravates the nutritional component of developing comorbid somatic pathology risk in the Arctic region. Against the background of alcohol dependence syndrome (ADS) development peculiar changes in lipid metabolism are revealed: a low low-density lipoproteins (LDL) and triglycerides (TG) content, but a high high-density lipoproteins (HDL) content. The revealed changes stimulate the search for new diagnostic approaches, with the help of which it is possible to identify hidden alcohol-associated changes in lipid metabolism and influence the mechanisms of cardiovascular system (CVS) pathology development at different stages. The aim was to identify lipid metabolism disorders in practically healthy individuals and in individuals with alcohol dependence to substantiate the specific clinical and biological syndrome isolation — alcoholic dyslipidemia and to develop an algorithm for detecting hidden alcohol-associated disorders. 208 men were examined: 96 people — with II stage SCA; 112 — practically healthy individuals. The content of total cholesterol, TG, HDL was determined by enzymatic colorimetric method, LDL — by turbidimetric method, concentrations of apolipoproteins (apo-A and apo-B) — by immuno-turbidimetric method, fatty acids — by gas-liquid chromatography. A low content of SFA (pentadecanoic, margarine, arachine, geneicosene), multidirectional changes in MSFA with a low content of myristooleic and eicosene lipid acids, but high palmitooleic and heptadecanoic; PUFA ω-6 linoleic, arachidonic. At the same time, an increase in the content of linoleic lipid acids trans-form was noted, the content of ω-3 PUFA was also lower than that of PP due to α-linolenic (C18:3ω3), docosohexaenoic (DHA), but the content of eicosopentaenoic (EPA) was higher. In narcological patients, weak correlations between LDL, TG and NLC were found, which indicates a lipid acids into LDL and TG integration violation. The absence of interrelations of ω-3 linoleic acid with EPA and DHA forming from it in patients with ADS may indicate anenzymatic processes violation.