Revascularization in Left Ventricular Systolic Dysfunction: A Meta-Analysis of Kaplan-Meier Reconstructed Individual Patient Data

BACKGROUND Coronary artery disease is a common etiology of ischemic left ventricular systolic dysfunction (LVSD), for which the optimal revascularization strategy remains unclear. We aimed to determine whether percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) results in greater survival advantage in patients with LVSD. METHODS A study-level (SLMA) and reconstructed individual patient data meta-analysis (rIPDMA) from Kaplan-Meier (KM) survival curves were performed. A systematic search of MEDLINE, EMBASE, and Cochrane was conducted for observational and randomized studies published after 2010 that compared PCI to CABG in patients with left ventricular ejection fraction ≤40%. The primary outcome was all-cause mortality at longest follow-up. The secondary outcomes were myocardial infarction (MI), stroke, repeat revascularization, cardiovascular mortality, and major adverse cardiovascular and cerebrovascular events (MACCE) at longest follow-up. RESULTS Fourteen studies (11 observational, three randomized, 13,063 patients) were eligible for SLMA. Seven contained digitizable KM curves from which individual patient data could be reconstructed. Study-level analysis found PCI associated with increased all-cause mortality (Hazard Ratio 1.41 [95% Confidence Interval 1.18-1.69]), MI (2.10 [1.62-2.72]), repeat revascularization (2.39 [1.37-4.17]) and MACCE (1.58 [1.23-2.03]), without significant differences in stroke (0.86 [0.39-1.92]) or cardiovascular mortality (1.42 [0.78-2.59]). In the rIPDMA, PCI resulted in increased all-cause mortality (1.57 [1.34-1.87]) and repeat revascularization (3.63 [3.12-4.21]) but overall lower risk of stroke (0.62 [0.39-0.99]) due to fewer events during initial follow-up. CONCLUSIONS In patients with ischemic LVSD, PCI was associated with higher risk of all-cause mortality and repeat revascularization than CABG but lower risk of short-term stroke.