Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.

Ziwei Liu,Clancy Zhijian Jiang, Andrew D Bond, Nicholas J Tosca, John D Sutherland

Chemical communications (Cambridge, England)（2024）

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摘要

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.

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