Rediscovering citrate as a biomarker for prostate cancer.

Lucas Galey,Ayokunle Olanrewaju,Hermann Nabi,Jean-Sébastien Paquette,Frédéric Pouliot,Étienne Audet-Walsh

Nature reviews. Urology（2024）

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Abstract

For many years, PSA has been the most commonly used biomarker for prostate cancer screening and diagnosis. Although serum PSA measurement is highly sensitive, this biomarker has several limitations. Citrate, a molecule closely linked to the unique metabolism of prostate cancer, has the potential to be used as a complementary biomarker alongside PSA.

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