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Mrna Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses Are Predictive of Serological Neutralization and Are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

Philip Samaan,Chapin S. Korosec,Patrick Budylowski,Serena L. L. Chau,Adrian Pasculescu,Freda Qi,Melanie Delgado-Brand,Tulunay R. Tursun,Genevieve Mailhot,Roya Monica Dayam,Corey R. Arnold,Marc-Andre Langlois, Justin Mendoza, Thomas Morningstar,Ryan Law, Erik Mihelic,Salma Sheikh-Mohamed,Eric Yixiao Cao,Nimitha Paul,Anjali Patel,Keelia Quinn de Launay,Jamie M. Boyd,Alyson Takaoka,Karen Colwill,Vitaliy Matveev,Feng Yun Yue,Allison Mcgeer,Sharon Straus,Anne-Claude Gingras, Jane M. Heffernen,Mario Ostrowski

JOURNAL OF VIROLOGY（2025）

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Key words
SARS-CoV-2,T-cell immunity,humoral immunity,mRNA vaccines,cross-reactivity,hybrid immunity
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