Aging, partial reprogramming and bioelectric fields: unveiling the path to cellular rejuvenation

The studies of rejuvenation are important for promoting health and longevity, preventing age-related diseases, reducing economic burdens, improving quality of life and addressing the challenges posed by an aging global population. This review explores the intersection of aging, regeneration and bioelectric fields examining the emerging role of membrane potential in processes like cell proliferation, differentiation, limb regeneration and potentially aging. Manipulation of membrane potential opens a novel dimension to the rejuvenation landscape offering an alternative or complementary approach to partial reprograming method presenting exciting possibilities for therapeutic interventions targeting age-related cellular changes.