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An Alternative Conformation of the N-terminal Loop of Human Dihydroorotate Dehydrogenase Drives Binding to a Potent Antiproliferative Agent.

Marta Alberti,Giulio Poli,Luca Broggini,Stefano Sainas,Menico Rizzi,Donatella Boschi,Davide M. Ferraris,Elena Martino,Stefano Ricagno,Tiziano Tuccinardi,Marco L. Lolli,Riccardo Miggiano

Acta Crystallographica Section D Structural Biology（2024）

Cited 0|Views21
Key words
pyrimidine biosynthesis,DHODH,human dihydroorotate dehydrogenase,structure-based drug discovery,X-ray crystallography
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