Insights from Multi-Omic Modeling of Neurodegeneration in Xeroderma Pigmentosum Using an Induced Pluripotent Stem Cell System

Cherif Badja,Sophie Momen,Gene Ching Chiek Koh,Soraya Boushaki,Theodoros I. Roumeliotis,Zuza Kozik, Ian Jones,Vicky Bousgouni,Joao M. L. Dias,Marios G. Krokidis,Jamie Young, Hongwei Chen,Ming Yang,France Docquier,Yasin Memari, Lorea Valcarcel-Zimenez,Komal Gupta,Li Ren Kong,Heather Fawcett, Florian Robert, Salome Zhao,Andrea Degasperi, Yogesh Kumar,Helen Davies,Rebecca Harris,Christian Frezza,Chryssostomos Chatgilialoglu,Robert Sarkany,Alan Lehmann,Chris Bakal,Jyoti Choudhary,Hiva Fassihi,Serena Nik-Zainal

Cell Reports（2024）

Cited 1|Views19

Key words

xeroderma pigmentosum,XP,iPSCs,DNA damage,oxidative stress,endoplasmic reticulum stress response,ubiquitin-proteasome system,UPS,neurodegeneration,early detection

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