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A Percutaneous Delivery System for a Nicotinamide Transdermal Therapeutic System

Inorganic Materials: Applied Research(2024)

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Abstract
Abstract—A percutaneous delivery system for nicotinamide is developed and its functional properties are studied in vitro. Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, docusate sodium, is varied. The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8
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Keywords: nicotinamide,transdermal delivery system,percutaneous delivery system,emulsion,diffusion of a drug substance
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