Synthesis of Amides via the Amination of Aldehydes with Hydroxylamines Promoted by TBAF·3H2O
The Journal of Organic Chemistry(2024)
摘要
A metal-free, mild, and efficient method for the synthesis of amides has been developed from the amination of aldehydes with hydroxylamines promoted by TBAF·3H2O in the presence of KOH. Control experiments showed that the nitrone was the intermediate of this amination. By this method, a series of amides, biologically active compounds bebenil and a COX inhibitor were obtained in moderate to good yields.
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