Successful treatment of epileptic encephalopathy with spike wave activation in sleep with anakinra
EPILEPSY & BEHAVIOR REPORTS(2024)
摘要
Patients with epileptic encephalopathy with spike wave activation in sleep (EE-SWAS) often display drugresistant epilepsy. The activation of epileptic activity during sleep is associated temporally with neurocognitive impairment and causes a spectrum of disorders within the epilepsy-aphasia syndrome. The prognosis is dependent on promptness of treatment and etiology. However, there is no clear consensus with regards to the optimal management for patients with EE-SWAS. We queried our Pediatric Epilepsy Outcome-Informatics Project (PEOIP) database for all patients treated with anakinra in our centre. We herein report a case of a female with EESWAS, who demonstrated remarkable neurocognitive improvement with anakinra. We suggest that a trial of anakinra may be an option for patients with EE-SWAS due to non-structural and possibly inflammatory etiology.
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关键词
Epileptic encephalopathy with spike wave,activation in sleep,Anakinra,CSWS,ESES,Epilepsy,Drug-resistant epilepsy,EE-SWAS,DEE-SWAS
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