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Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles

M. V. Filimonova,D. D. Kolmanovich,G. V. Tikhonowski, D. S. Petrunya,P. A. Kotelnikova,A. A. Shitova,O. V. Soldatova,A. S. Filimonov,V. A. Rybachuk,A. O. Kosachenko, K. A. Nikolaev,G. A. Demyashkin,A. A. Popov,M. S. Savinov,A. L. Popov,I. V. Zelepukin,A. A. Lipengolts,K. E. Shpakova,A. V. Kabashin,S. N. Koryakin,S. M. Deyev,I. N. Zavestovskaya

Doklady Biochemistry and Biophysics（2024）

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Abstract
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80
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Key words
proton therapy,radiosensitizers,nanoparticles,gold,tumor therapy
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