qtOCT: quantitative transmission optical coherence tomography
arxiv(2024)
Abstract
Transmission optical coherence tomography (OCT) enables analysis of
biological specimens in vitro through detection of forward scattered light. Up
to now, transmission OCT was considered as a technique that cannot directly
retrieve quantitative phase and is thus a qualitative method. In this paper, we
present qtOCT, a novel quantitative transmission optical coherence tomography
method. Unlike existing approaches, qtOCT allows for a direct, easy, fast and
rigorous retrieval of 2D integrated phase information from transmission
full-field swept-source OCT measurements. Our method is based on coherence
gating and allows user-defined temporal measurement range selection, making it
potentially suitable for analyzing multiple-scattering samples. We demonstrate
high consistency between qtOCT and digital holographic microscopy phase images.
This approach enhances transmission OCT capabilities, positioning it as a
viable alternative to quantitative phase imaging techniques.
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