Preparation of woven scaffolds with porous structure and piezoelectric stimulation capability for osteoblast regeneration

Bone tissue generates many biological signals during self-repair and regeneration, of which the transmission of electrical signals is critical to the success of bone repair. Therefore, in this study, barium titanate/hydroxyapatite(BT/HA) composite nanoparticles were synthesized using a hydrothermal method at 170°C, and BT/HA scaffolds with piezoelectric stimulation were prepared by blending them with sodium alginate in combination with two-dimensional braided tubes. The scaffolds were distributed with a pore size of 30-100 μm, a porosity of 60%-70%, a swelling rate of more than 300%, and output voltages and currents of about 800mV and 2.4 μA. The degradation rate reached 3.59% after 21 days, and in vitro cell cultures confirmed that polarised scaffolds could further promote cell proliferation and differentiation. The cell survival rate on the polarised scaffold was 174.77%. This study provides a new idea for the combination of piezoelectric materials and woven structures, which can be potentially applied to the field of bone repair.