Associations between triglyceride-glucose index and risk of diabetic kidney disease progression in type 2 diabetes mellitus

Pending connections exist between the TyG index and the risk assessment of diabetic kidney disease (DKD), which includes glomerular filtration rate and urine albumin to creatinine ratio. DKD progression risk and the TyG index were examined in this study. Following the Kidney Disease: Improving Global Outcomes guidelines, combined with ACR and eGFR, the risk of DKD progression was divided into three groups: low risk (group 1), moderately increased risk (group 2), and high to very high risk (group 3) (group 3, which combined the high and very high risk in the guidelines). Groups’ TyG index differences were compared. The association between the TyG index of patients and the risk of developing type 2 diabetic nephropathy was analyzed via linear and logistic regression. The TyG index varied tremendously between risk groups (p < 0.001). In both sexes, multivariate analysis revealed that the TyG index was significantly associated with the moderately increased risk (male: β = 0.186, p < 0.001; female: β = 0.339, p < 0.001) and high to very high risk (male: β = 0.186, p < 0.001; female: β = 0.181, p = 0.009) of DKD progression. Logistic regression analysis showed a higher risk of increased TyG index in men compared to group 1. In patients with type 2 diabetes, the TyG index was associated with the risk of DKD progression, which increased by an elevated TyG index in male patients—supporting the clinical significance of the TyG index for assessing the risk of DKD progression.