Pd(II)-Catalyzed Desymmetrizing gem-Dimethyl C(sp³)-H Alkenylation/Aza-Wacker Cyclization Directed by PIP Auxiliary

Desymmetrization of gem-dimethyl groups has been developed as an efficient pathway to achieve asymmetric C(sp(3))-H functionalization. Herein, we described a Pd(II)-catalyzed desymmetrizing gem-dimethyl C(sp(3))-H alkenylation/aza-Wacker cyclization directed by a bidentate 2-pyridinylisopropyl auxiliary. Chiral alpha-methyl gamma-lactams were obtained in good yields (up to 82%) and high enantioselectivities (up to 91.5% ee).