Indications and yield of Fresh Frozen Plasma in massive hemorrhage, efficiency biological monitoring. Preliminary results

Abstract The aim of the study was to examine various haemostasis values to identify the most relevant biological indicators for detecting significant hemorrhage, to determine the effectiveness of fresh frozen plasma (FFP) transfusion. Our findings suggest that a low prothrombin time, elevated Von Willebrand Antigen, increased plasma fibrinogen, and reduced Ca2+ levels are associated with challenges in achieving proper hemostasis. However, measurements of factors II, V, VII, VIII, IX, X, XI, XIII, protein C, and protein S do not appear to be linked to difficulties in achieving adequate haemostasis. Additionally, the administration of FFP appears to impact factors V, VII, X, and II. Trial registration EudraCT number: 2019-002898-64