Reperfusion therapies in patients with acute ischaemic stroke and atrial fibrillation: data on safety and effectiveness from a multi-centre cohort study

Virginia Cancelloni, Mariachiara Buratti,Georgios Tsivgoulis,Karen L. Furie,Prasanna Tadi,Valeria Caso,Cecilia Becattini,Giancarlo Agnelli,Marialuisa Zedde,Azmil H. Abdul-Rahim,Andrea Alberti,Michele Venti,Ilaria Leone de Magistris,Monica Acciarresi, Cataldo D’Amore, Maria G. Mosconi, Ludovica A. Cimini,Manuel Cappellari,Jukka Putaala,Liisa Tomppo,Turgut Tatlisumak,Fabio Bandini,Simona Marcheselli,Alessandro Pezzini, Sung-I. I. Sohn, Gianni Lorenzini,Rossana Tassi,Francesca Guideri,Maurizio Acampa,George Ntaios,Efstathia Karagkiozi, George Athanasakis, Kostantinos Makaritsis,Dimitrios Sagris, Anastasia Adamou, Kostantinos Vadikolias,Lina Palaiodimou,Maria Chondrogianni,Nicola Mumoli,Franco Galati,Simona Sacco,Cindy Tiseo,Francesco Corea,Walter Ageno, Marta Bellesini,Giorgio Silvestrelli,Alfonso Ciccone,Michelangelo Mancuso,Giovanni Orlandi,Rosario Pascarella,Tiziana Tassinari,Christina Rueckert,Antonio Baldi,Danilo Toni, Federica Lettieri,Martina Giuntini, Enrico M. Lotti,Yuriy Flomin,Alessio Pieroni,Odysseas Kargiotis,Theodore Karapanayiotides, Panagiotis Halvatsiotis, Serena Monaco, Mario M. Baronello,Laszlò Csiba,Lilla Szabò, Alberto Chiti,Elisa Giorli,Massimo Del Sette,Davide Imberti,Dorjan Zabzuni,Boris Doronin,Vera Volodina,Patrik Michel,Peter Vanacker,Kristian Barlinn,Lars P. Pallesen,Jessica Kepplinger,Dirk Deleu, Vanessa Gourbali,Shadi Yaghi,Maurizio Paciaroni

Neurological Sciences（2024）

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Abstract

Intravenous thrombolysis (IVT) and/or endovascular therapy (EVT) are currently considered best practices in acute stroke patients. Data regarding the efficacy and safety of reperfusion therapies in patients with atrial fibrillation (AF) are conflicting as regards haemorrhagic transformation, mortality, and functional outcome. This study sought to investigate for any differences, in terms of safety and effectiveness, between AF patients with acute ischaemic stroke (AIS) treated and untreated with reperfusion therapies. Data from two multicenter cohort studies (RAF and RAF-NOACs) on consecutive patients with AF and AIS were analyzed to compare patients treated and not treated with reperfusion therapies (IVT and/or EVT). Multivariable logistic regression analysis was performed to identify independent predictors for outcome events: 90-day good functional outcome and mortality. A propensity score matching (PSM) analysis compared treated and untreated patients. Overall, 441 (25.4

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Key words

ischaemic stroke,atrial fibrillation,reperfusion therapies,intravenous thrombolysis,endovascular therapy,outcome

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