Proline-derived dichlorophenyl-substituted urea as catalyst for “on-water” asymmetric addition reactions of oxoindoles to nitroolefins
Tetrahedron Letters(2024)
摘要
The dichlorophenyl-substituted chiral urea derived from proline was designed and synthesized as a bifunctional organocatalyst for the “on-water” asymmetric Michael addition of less-hydrophobic oxoindoles to nitroolefins. Employing only 1 mol% of this bifunctional organocatalyst demonstrated exceptional catalytic efficiency (>90 % yield in most cases) and stereoselectivity in reactions involving various 3-substituted oxoindoles (up to > 99 % de and 96 % ee) and nitroolefins (up to > 99 % de and 98 % ee).
更多查看译文
关键词
Proline-derived chiral urea,“On-water” organocatalysis,Dichlorophenyl substituent,Oxoindoles
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要