An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH.

Yaxin Sun,Yanyun Mao,Tianwen Bai,Tianqing Ye,Yanfei Lin, Fang Wang,Lei Li,Longhua Guo,Haiying Liu,Jianbo Wang

Chemical communications (Cambridge, England)（2024）

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摘要

A novel NIR fluorescent probe based on quinoline-conjugated benzo[cd]indol dual-salt for NADH was developed. This probe swiftly detects and responds sensitively to both endogenous and exogenous NADH alterations, enabling imaging of NADH fluctuations in type II diabetic and AD model cells.

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