Mechanistic Safety Assessment Via Multi-Omic Characterisation of Systemic Pathway Perturbations Following in Vivo MAT2A Inhibition.
Valentina Fogal,Filippos Michopoulos,Andrew F. Jarnuczak,Ghaith M. Hamza,Stephanie Harlfinger,Paul Davey,Heather Hulme,Stephen J. Atkinson, Piotr Gabrowski,Tony Cheung,Michael Grondine,Clare Hoover,Jonathan Rose, Chandler Bray,Alison J. Foster,Sean Askin, Muntasir Mamun Majumder, Paul Fitzpatrick,Eric Miele,Ruth Macdonald,Hector C. Keun,Muireann Coen Archives of Toxicology（2024）
关键词
One-carbon metabolism,MAT2A enzyme,Drug safety,Methionine metabolism,Metabolomics,Multi-omics
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