Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

Richard A. Miller,David E. Harrison,Gino A. Cortopassi, Ishmael Dehghan,Elizabeth Fernandez,Michael Garratt,John G. Geisler,Brett C. Ginsburg,Melissa L. Han,Catherine C. Kaczorowski,Navasuja Kumar,Scott F. Leiser,Marisa Lopez-Cruzan,Ginger Milne, James R. Mitchell,James F. Nelson,Peter C. Reifsnyder,Adam B. Salmon,Ron Korstanje,Nadia Rosenthal,Randy Strong

GeroScience（2024）

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摘要

Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol (DNP), hydralazine (HYD), nebivolol (NEBI), 16α-hydroxyestriol (OH_Est), and sodium thiosulfate (THIO), and to evaluate the effects of canagliflozin (Cana) when started at 16 months of age. OH_Est produced a 15

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关键词

Alpha-ketoglutarate,SGLT2 inhibitor Canagliflozin,Lifespan

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