Tenascin-C in patients with central nervous system infections
Journal of Neuroimmunology(2024)
Abstract
Background
The extracellular matrix protein tenascin-C has been discovered to be an important regulator of the response to tissue injury and repair in cerebrovascular diseases. This study investigated if tenascin-C is released in response to infections in the central nervous system (CNS).
Methods
Tenascin-C concentration in the cerebrospinal fluid (CSF) was measured in patients, (>18 years) with and without CNS infections, admitted to a department of infectious diseases in Denmark. CSF tenascin-C was measured on the Meso-scale platform.
Results
174 patients were included of which 140 were diagnosed with a CNS infection and 34 where this was ruled out (control group). Median CSF tenascin-C levels were significantly higher among patients with bacterial meningitis (147 pg/ml), viral meningitis (33 mg/ml), viral encephalitis (39 pg/ml) and Lyme neuroborreliosis (45 pg/ml) when compared to controls (21 pg/ml). Correlations between tenascin-C and CSF markers of inflammation and age were only moderate.
Conclusion
Levels of CSF tenascin-C are higher among patients with bacterial and viral neuroinfections, already on admission, but exhibit only a modest correlation with baseline indices of neuroinflammation. CSF tenascin-C is highest among patients with bacterial meningitis compared to the other CNS infections. Patients with unfavorable outcomes presented with higher median CSF tenascin-C than their counterparts.
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Key words
Central nervous system infections,Bacterial meningitis,Viral meningitis,Viral encephalitis,Lyme neuroborreliosis,Tenascin-C
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