Remimazolam for the prevention of emergence agitation in adult following nasal surgery under general anesthesia: A randomized controlled study
crossref(2024)
Abstract
Abstract The purpose of this study was to evaluate the effectiveness of postoperative use of remimazolam in preventing emergence agitation (EA) in adult following nasal surgery. In total, 86 patients underwent nasal surgery were randomly divided into two groups. Propofol, sufentanil and cis-atracuriumwere used for induction of anaesthesia, then sevoflurane concentration and propofol were used for maintenance of anaesthesia. After surgery, patients were randomly assigned to receive either remimazolam 0.1 mg/kg (Group R, n = 43) or 0.9% normal saline (Group C, n = 43). The outcomes included the incidence of EA, severe EA, extubation time, length of PACU stay and the maximal RSAS score. In this study. The incidence of EA was lower in Group R than in Group C (21% vs 49%, P = 0.007). The incidence of severe EA was also lower in Group R than in Group C (2% vs 19%, P = 0.035). The maximal RSAS score during emergence was lower in Group R (4 [4–4]) than in Group C (5 [4–6]) (P < 0.001). Therefore, postoperative injection of remimazolam 0.1 mg/kginto adult patients underwent nasal surgerycan significantly reduce the incidence of EA and severe EA.
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